منابع مشابه
Lipid Raft Microdomains
Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding. Filoviruses released from infected cells incorporated raft-associated molecules, suggestin...
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The sarcolemma of smooth muscle cells is composed of alternating stiff actin-binding, and flexible caveolar domains. In addition to these stable macrodomains, the plasma membrane contains dynamic glycosphingolipidand cholesterol-enriched microdomains, which act as sorting posts for specific proteins and are involved in membrane trafficking and signal transduction. We demonstrate that these lipi...
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9 REVIEW OF THE LITERATURE 11 1. Cell membranes and cholesterol 11 1.1 Cellular membranes 11 1.1.1 Basic structure and components 11 1.1.2 Cholesterol-sphingolipid interaction 14 1.1.3 Distribution of cholesterol and other lipids in cell membranes 15 1.2 Cholesterol homeostasis in mammalian cells 16 1.2.1 Cholesterol biosynthesis, lipoprotein uptake and cholesterol efflux 16 1.2.2 Cholesterol e...
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A microfluidic bilayer lipid membrane (BLM) system supporting correlated opto-electrical membrane characterization has been developed and applied to the imaging of phase-separated lipid microdomains by confocal microscopy. The device consists of a microfluidic network supporting rapid perfusion fabricated in a thermoplastic substrate, bonded to a thin PVDC partition and supported by a thin cove...
متن کاملProperties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy.
The lateral motion of single fluorescence labeled lipid molecules was imaged in native cell membranes on a millisecond time scale and with positional accuracy of approximately 50 nm, using 'single dye tracing'. This first application of single molecule microscopy to living cells rendered possible the direct observation of lipid-specific membrane domains. These domains were sensed by a lipid pro...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2008
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e08-05-0517